Endocrine Abstracts

Objective: The aim of the present study was to determine whether insulin resistance is important in well controlled, uncomplicated patients with type 1 diabetes on long term CSII, compared to matched healthy controls.Research design and methods: We studied 8 patients (4 men and 4 women) with type 1 diabetes on stable continuous subcutaneous insulin pump therapy and 8 healthy controls, matched for age, gender and BMI. Insulin sensitivity was measured by h...

Background: Human sleep is composed of different sleep stages, of which slow wave sleep (SWS) is an important modulator of glucose regulation. Curtailment of sleep duration in general and of slow wave sleep (SWS) in particular reduces glucose tolerance in healthy subjects. Previously, we have reported that a single night of partial sleep deprivation reduces insulin sensitivity by 15–20% in patients with type 1 diabetes. We hypothesized that this effect could be a conseque...

Introduction: Sleep restriction and/or impaired sleep quality negatively influence glucoregulation. The aim of this study was to assess subjective sleep parameters in patients with type 1 diabetes, to relate sleep parameters to long-term glycaemic control, and to assess possible risk factors for impaired sleep.Research design and methods: We studied 99 adult patients with type 1 diabetes (55M, 44F, duration of diabetes 26.9±1.2 years) and 99 age-, g...

Context and objective: Fatigue and excessive sleepiness have been reported after treatment of nonfunctioning pituitary macroadenomas (NFMA). Because these complaints may be caused by disturbed nocturnal sleep, we evaluated objective sleep characteristics in patients treated for NFMA.Design: Controlled cross-sectional study.Subjects and methods: We studied 17 patients (8 women, mean age 54 years), in remission of NFMA during long-te...